Ontology highlight
ABSTRACT:
SUBMITTER: Manas A
PROVIDER: S-EPMC6022363 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Mañas Adriana A Chen Wenjing W Nelson Adam A Yao Qi Q Xiang Jialing J
Biochemical and biophysical research communications 20171229 1
Proteasome inhibitors, such as bortezomib and carfilzomib, are FDA approved for the treatment of hemopoietic cancers, but recent studies have shown their great potential for treatment of solid tumors. BaxΔ2, a unique proapoptotic Bax isoform, promotes non-mitochondrial cell death and sensitizes cancer cells to chemotherapy. However, endogenous BaxΔ2 proteins are unstable and susceptible to proteasomal degradation. Here, we screened a panel of proteasome inhibitors in colorectal cancer cells with ...[more]