Ontology highlight
ABSTRACT:
SUBMITTER: Rauch A
PROVIDER: S-EPMC6021236 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Rauch Anke A Carlstedt Annemarie A Emmerich Claudia C Mustafa Al-Hassan M AM Göder Anja A Knauer Shirley K SK Linnebacher Michael M Heinzel Thorsten T Krämer Oliver H OH
Oncotarget 20180612 45
Irinotecan (CPT-11) and oxaliplatin (L-OHP) are among the most frequently used drugs against colorectal tumors. Therefore, it is important to define the molecular mechanisms that these agents modulate in colon cancer cells. Here we demonstrate that CPT-11 stalls such cells in the G<sub>2</sub>/M phase of the cell cycle, induces an accumulation of the tumor suppressor p53, the replicative stress/DNA damage marker γH2AX, phosphorylation of the checkpoint kinases ATM and ATR, and an ATR-dependent a ...[more]