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PBRIT: gene prioritization by correlating functional and phenotypic annotations through integrative data fusion.


ABSTRACT: Motivation:Computational gene prioritization can aid in disease gene identification. Here, we propose pBRIT (prioritization using Bayesian Ridge regression and Information Theoretic model), a novel adaptive and scalable prioritization tool, integrating Pubmed abstracts, Gene Ontology, Sequence similarities, Mammalian and Human Phenotype Ontology, Pathway, Interactions, Disease Ontology, Gene Association database and Human Genome Epidemiology database, into the prediction model. We explore and address effects of sparsity and inter-feature dependencies within annotation sources, and the impact of bias towards specific annotations. Results:pBRIT models feature dependencies and sparsity by an Information-Theoretic (data driven) approach and applies intermediate integration based data fusion. Following the hypothesis that genes underlying similar diseases will share functional and phenotype characteristics, it incorporates Bayesian Ridge regression to learn a linear mapping between functional and phenotype annotations. Genes are prioritized on phenotypic concordance to the training genes. We evaluated pBRIT against nine existing methods, and on over 2000 HPO-gene associations retrieved after construction of pBRIT data sources. We achieve maximum AUC scores ranging from 0.92 to 0.96 against benchmark datasets and of 0.80 against the time-stamped HPO entries, indicating good performance with high sensitivity and specificity. Our model shows stable performance with regard to changes in the underlying annotation data, is fast and scalable for implementation in routine pipelines. Availability and implementation:http://biomina.be/apps/pbrit/; https://bitbucket.org/medgenua/pbrit. Supplementary information:Supplementary data are available at Bioinformatics online.

SUBMITTER: Kumar AA 

PROVIDER: S-EPMC6022555 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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pBRIT: gene prioritization by correlating functional and phenotypic annotations through integrative data fusion.

Kumar Ajay Anand AA   Van Laer Lut L   Alaerts Maaike M   Ardeshirdavani Amin A   Moreau Yves Y   Laukens Kris K   Loeys Bart B   Vandeweyer Geert G  

Bioinformatics (Oxford, England) 20180701 13


<h4>Motivation</h4>Computational gene prioritization can aid in disease gene identification. Here, we propose pBRIT (prioritization using Bayesian Ridge regression and Information Theoretic model), a novel adaptive and scalable prioritization tool, integrating Pubmed abstracts, Gene Ontology, Sequence similarities, Mammalian and Human Phenotype Ontology, Pathway, Interactions, Disease Ontology, Gene Association database and Human Genome Epidemiology database, into the prediction model. We explor  ...[more]

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