Ontology highlight
ABSTRACT:
SUBMITTER: Barnaba C
PROVIDER: S-EPMC6022741 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Chemical communications (Cambridge, England) 20180601 49
Lipids are critical for the function of membrane proteins. NADPH-cytochrome-P450-reductase, the sole electron transferase for microsomal oxygenases, possesses a conformational dynamics entwined with its topology. Here, we use peptide-nanodiscs to unveil cytochrome-P450-reductase's lipid boundaries, demonstrating a protein-driven enrichment of ethanolamine lipids (by 25%) which ameliorates by 3-fold CPR's electron-transfer ability. ...[more]