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Genomic Influence in the Prevention of Cardiovascular Diseases with a Sterol-Based Treatment.

ABSTRACT: Raised serum cholesterol concentration is a well-established risk factor in cardiovascular disease. In addition, genetic load may have an indirect influence on cardiovascular risk. Plant-based sterol-supplemented foods are recommended to help reduce the serum low-density lipoprotein cholesterol level. The objective was to analyse the influence of different polymorphisms in hypercholesterolemia patients following a dietary treatment with plant sterols. A randomised double-blind cross-over controlled clinical trial was carried out in 45 people (25 women). Commercial milk, containing 2.24 g of sterols, was ingested daily during a 3-week period, and then the same amount of skim milk, without sterols, was consumed daily during the 3-week placebo phase. Both phases were separated by a washout period of 2 weeks. At the beginning and end of each phase, blood draws were performed. Genes LIPC C-514T and APOA5 C56G are Ser19Trp carriers and greatly benefit from sterol intake in the diet. LIPC C-514T TT homozygous carriers had lower low-density lipoprotein cholesterol (LDL-c) levels than CC homozygote and CT heterozygote carriers after the ingestion of plant sterols (p = 0.001). These two genes also showed statistically significant changes in total cholesterol levels (p = 0.025; p = 0.005), and no significant changes in high-density lipoprotein (HDL) cholesterol levels (p = 0.032; p = 0.003), respectively. No statistically significant differences were observed for other genes. Further studies are needed to establish which genotype combinations would be the most protective against hypercholesterolemia.

SUBMITTER: San Mauro Martin I

PROVIDER: S-EPMC6023396 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Genomic Influence in the Prevention of Cardiovascular Diseases with a Sterol-Based Treatment.

San Mauro Martín Ismael I San Mauro Martín Ismael I Blumenfeld Olivares Javier Andrés JA Pérez Arruche Eva E Arce Delgado Esperanza E Ciudad Cabañas María José MJ Garicano Vilar Elena E Collado Yurrita Luis L

Diseases (Basel, Switzerland) 20180403 2

Raised serum cholesterol concentration is a well-established risk factor in cardiovascular disease. In addition, genetic load may have an indirect influence on cardiovascular risk. Plant-based sterol-supplemented foods are recommended to help reduce the serum low-density lipoprotein cholesterol level. The objective was to analyse the influence of different polymorphisms in hypercholesterolemia patients following a dietary treatment with plant sterols. A randomised double-blind cross-over control ...[more]

PMID: 29614023

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Genomic Influence in the Prevention of Cardiovascular Diseases with a Sterol-Based Treatment.

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Genomic Influence in the Prevention of Cardiovascular Diseases with a Sterol-Based Treatment.

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