Ontology highlight
ABSTRACT:
SUBMITTER: Englezou PC
PROVIDER: S-EPMC6023837 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Englezou Pavlos C PC Sapet Cedric C Démoulins Thomas T Milona Panagiota P Ebensen Thomas T Schulze Kai K Guzman Carlos-Alberto CA Poulhes Florent F Zelphati Olivier O Ruggli Nicolas N McCullough Kenneth C KC
Molecular therapy. Nucleic acids 20180504
Advances in RNA technology during the past two decades have led to the construction of replication-competent RNA, termed replicons, RepRNA, or self-amplifying mRNA, with high potential for vaccine applications. Cytosolic delivery is essential for their translation and self-replication, without infectious progeny generation, providing high levels of antigen expression for inducing humoral and cellular immunity. Synthetic nanoparticle-based delivery vehicles can both protect the RNA molecules and ...[more]