Ontology highlight
ABSTRACT:
SUBMITTER: Mortuza GB
PROVIDER: S-EPMC6023931 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Mortuza Gulnahar B GB Hermida Dario D Pedersen Anna-Kathrine AK Segura-Bayona Sandra S López-Méndez Blanca B Redondo Pilar P Rüther Patrick P Pozdnyakova Irina I Garrote Ana M AM Muñoz Inés G IG Villamor-Payà Marina M Jauset Cristina C Olsen Jesper V JV Stracker Travis H TH Montoya Guillermo G
Nature communications 20180628 1
Tousled-like kinases (TLKs) are required for genome stability and normal development in numerous organisms and have been implicated in breast cancer and intellectual disability. In humans, the similar TLK1 and TLK2 interact with each other and TLK activity enhances ASF1 histone binding and is inhibited by the DNA damage response, although the molecular mechanisms of TLK regulation remain unclear. Here we describe the crystal structure of the TLK2 kinase domain. We show that the coiled-coil domai ...[more]