Ontology highlight
ABSTRACT:
SUBMITTER: Peti W
PROVIDER: S-EPMC3843625 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Peti Wolfgang W Page Rebecca R
Protein science : a publication of the Protein Society 20131019 12
Mitogen-activated protein kinases (MAPKs; ERK1/2, p38, JNK, and ERK5) have evolved to transduce environmental and developmental signals (growth factors, stress) into adaptive and programmed responses (differentiation, inflammation, apoptosis). Almost 20 years ago, it was discovered that MAPKs contain a docking site in the C-terminal lobe that binds a conserved 13-16 amino acid sequence known as the D- or KIM-motif (kinase interaction motif). Recent crystal structures of MAPK:KIM-peptide complexe ...[more]