Ontology highlight
ABSTRACT:
SUBMITTER: Shimura N
PROVIDER: S-EPMC6024299 | biostudies-literature | 2018 Apr-Jun
REPOSITORIES: biostudies-literature
Shimura Noriko N Kojima Shuji S
Dose-response : a publication of International Hormesis Society 20180401 2
We herein attempted to identify the lowest radiation dose causing molecular changes in the living body. We investigated the effects of radiation in human cells, animals, and humans. DNA double-strand breaks (DSBs) formed in cells at γ- or X-ray irradiation doses between 1 mGy and 0.5 Gy; however, the extent of DSB formation differed depending on the cell species. The formation of micronuclei (MNs) and nucleoplasmic bridges (NPBs) was noted at radiation doses between 0.1 and 0.2 Gy. Stress-respon ...[more]