Ontology highlight
ABSTRACT:
SUBMITTER: Abaandou L
PROVIDER: S-EPMC6024716 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Abaandou Laura L Shiloach Joseph J
Medical sciences (Basel, Switzerland) 20180608 2
Creating efficient cell lines is a priority for the biopharmaceutical industry, which produces biologicals for various uses. A recent approach to achieving this goal is the use of non-coding RNAs, microRNA (miRNA) and small interfering RNA (siRNA), to identify key genes that can potentially improve production or growth. The ornithine decarboxylase antizyme 1 (<i>OAZ1</i>) gene, a negative regulator of polyamine biosynthesis, was identified in a genome-wide siRNA screen as a potential engineering ...[more]