Ontology highlight
ABSTRACT:
SUBMITTER: Clayton KL
PROVIDER: S-EPMC6025741 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Clayton Kiera L KL Collins David R DR Lengieza Josh J Ghebremichael Musie M Dotiwala Farokh F Lieberman Judy J Walker Bruce D BD
Nature immunology 20180418 5
CD4<sup>+</sup> T lymphocytes are the principal target of human immunodeficiency virus (HIV), but infected macrophages also contribute to viral pathogenesis. The killing of infected cells by CD8<sup>+</sup> cytotoxic T lymphocytes (CTLs) leads to control of viral replication. Here we found that the killing of macrophages by CTLs was impaired relative to the killing of CD4<sup>+</sup> T cells by CTLs, and this resulted in inefficient suppression of HIV. The killing of macrophages depended on casp ...[more]