Ontology highlight
ABSTRACT:
SUBMITTER: Boliar S
PROVIDER: S-EPMC6462110 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Boliar Saikat S Gludish David W DW Jambo Kondwani C KC Kamng'ona Raphael R Mvaya Leonard L Mwandumba Henry C HC Russell David G DG
Proceedings of the National Academy of Sciences of the United States of America 20190327 15
Long noncoding RNAs (lncRNAs) impart significant regulatory functions in a diverse array of biological pathways and manipulation of these RNAs provides an important avenue to modulate such pathways, particularly in disease. Our knowledge about lncRNAs' role in determination of cellular fate during HIV-1 infection remains sparse. Here, we have identified the impact of the lncRNA SAF in regulating apoptotic effector caspases in macrophages, a long-lived cellular reservoir of HIV-1, that are largel ...[more]