Ontology highlight
ABSTRACT:
SUBMITTER: Chennamadhavuni D
PROVIDER: S-EPMC6025895 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Chennamadhavuni Divya D Saavedra-Avila Noemi Alejandra NA Carreño Leandro J LJ Guberman-Pfeffer Matthew J MJ Arora Pooja P Yongqing Tang T Pryce Rhys R Koay Hui-Fern HF Godfrey Dale I DI Keshipeddy Santosh S Richardson Stewart K SK Sundararaj Srinivasan S Lo Jae Ho JH Wen Xiangshu X Gascón José A JA Yuan Weiming W Rossjohn Jamie J Le Nours Jérôme J Porcelli Steven A SA Howell Amy R AR
Cell chemical biology 20180322 5
Glycosylceramides that activate CD1d-restricted invariant natural killer T (iNKT) cells have potential therapeutic applications for augmenting immune responses against cancer and infections. Previous studies using mouse models identified sphinganine variants of α-galactosylceramide as promising iNKT cell activators that stimulate cytokine responses with a strongly proinflammatory bias. However, the activities of sphinganine variants in mice have generally not translated well to studies of human ...[more]