Ontology highlight
ABSTRACT:
SUBMITTER: Hirukawa A
PROVIDER: S-EPMC6026192 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Nature communications 20180629 1
Emerging evidence has illustrated the importance of epigenomic reprogramming in cancer, with altered post-translational modifications of histones contributing to pathogenesis. However, the contributions of histone modifiers to breast cancer progression are unclear, and how these processes vary between molecular subtypes has yet to be adequately addressed. Here we report that genetic or pharmacological targeting of the epigenetic modifier Ezh2 dramatically hinders metastatic behaviour in both a m ...[more]