Ontology highlight
ABSTRACT:
SUBMITTER: Hou S
PROVIDER: S-EPMC6400538 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20190131 3
Follicular regulatory T (Tfr) cells are a regulatory T cell subset that controls antibody production by inhibiting T follicular helper (Tfh)-mediated help to B cells. Tfh and Tfr cells possess opposing functions suggesting unique programming. Here we elucidated the transcriptional program controlling Tfr suppressive function. We found that Tfr cells have a program for suppressive function fine-tuned by tissue microenvironment. The transcription factor FoxP3 and chromatin-modifying enzyme EZH2 ar ...[more]