Ontology highlight
ABSTRACT:
SUBMITTER: Zitnik M
PROVIDER: S-EPMC6026212 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Zitnik Marinka M Sosič Rok R Leskovec Jure J
Nature communications 20180629 1
Uncovering modular structure in networks is fundamental for systems in biology, physics, and engineering. Community detection identifies candidate modules as hypotheses, which then need to be validated through experiments, such as mutagenesis in a biological laboratory. Only a few communities can typically be validated, and it is thus important to prioritize which communities to select for downstream experimentation. Here we develop CRANK, a mathematically principled approach for prioritizing ne ...[more]