Ontology highlight
ABSTRACT:
SUBMITTER: Yan L
PROVIDER: S-EPMC6026448 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Yan Le L Ravasio Riccardo R Brito Carolina C Wyart Matthieu M
Biophysical journal 20180601 12
Allosteric proteins transmit a mechanical signal induced by binding a ligand. However, understanding the nature of the information transmitted and the architectures optimizing such transmission remains a challenge. Here we show, using an in silico evolution scheme and theoretical arguments, that architectures optimized to be cooperative, which efficiently propagate energy, qualitatively differ from previously investigated materials optimized to propagate strain. Although we observe a large diver ...[more]