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One-pot multicomponent nitro-Mannich reaction using a heterogeneous catalyst under solvent-free conditions.

ABSTRACT: An environmentally-friendly, one-pot multicomponent reaction of various aldehydes, amines and nitroalkanes for the synthesis of ?-nitroamines is here described. Amberlyst A-21 supported CuI was found to be a highly efficient novel heterogeneous catalyst for the three-component nitro-Mannich reaction between aldehydes, amines and nitroalkanes. The developed protocol is performed in a solvent-free medium to produce a variety of ?-nitroamines in good to excellent yields within short reaction times. The catalyst can be easily prepared and recovered. It has been tested up to eight times with only a minor activity loss.

SUBMITTER: Bosica G

PROVIDER: S-EPMC6026460 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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One-pot multicomponent nitro-Mannich reaction using a heterogeneous catalyst under solvent-free conditions.

Bosica Giovanna G Zammit Ramon R

PeerJ 20180627

An environmentally-friendly, one-pot multicomponent reaction of various aldehydes, amines and nitroalkanes for the synthesis of β-nitroamines is here described. Amberlyst A-21 supported CuI was found to be a highly efficient novel heterogeneous catalyst for the three-component nitro-Mannich reaction between aldehydes, amines and nitroalkanes. The developed protocol is performed in a solvent-free medium to produce a variety of β-nitroamines in good to excellent yields within short reaction times. ...[more]

PMID: 29967735

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