Unknown

Dataset Information

0

Hypoxia-Induced MicroRNA-210 Targets Neurodegenerative Pathways.


ABSTRACT: Hypoxia-regulated microRNA-210 (miR-210) is a highly conserved microRNA, known to regulate various processes under hypoxic conditions. Previously we found that miR-210 is also involved in honeybee learning and memory, raising the questions of how neural activity may induce hypoxia-regulated genes and how miR-210 may regulate plasticity in more complex mammalian systems. Using a pull-down approach, we identified 620 unique target genes of miR-210 in humans, among which there was a significant enrichment of age-related neurodegenerative pathways, including Huntington's, Alzheimer's, and Parkinson's diseases. We have also validated that miR-210 directly regulates various identified target genes of interest involved with neuronal plasticity, neurodegenerative diseases, and miR-210-associated cancers. This data suggests a potentially novel mechanism for how metabolic changes may couple plasticity to neuronal activity through hypoxia-regulated genes such as miR-210.

SUBMITTER: Watts ME 

PROVIDER: S-EPMC6027187 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Hypoxia-Induced MicroRNA-210 Targets Neurodegenerative Pathways.

Watts Michelle E ME   Williams Sarah M SM   Nithianantharajah Jess J   Claudianos Charles C  

Non-coding RNA 20180327 2


Hypoxia-regulated microRNA-210 (miR-210) is a highly conserved microRNA, known to regulate various processes under hypoxic conditions. Previously we found that miR-210 is also involved in honeybee learning and memory, raising the questions of how neural activity may induce hypoxia-regulated genes and how miR-210 may regulate plasticity in more complex mammalian systems. Using a pull-down approach, we identified 620 unique target genes of miR-210 in humans, among which there was a significant enr  ...[more]

Similar Datasets

| S-EPMC10095479 | biostudies-literature
| S-EPMC6556335 | biostudies-literature
| S-EPMC7973385 | biostudies-literature
| S-EPMC6093025 | biostudies-literature
| S-EPMC5413434 | biostudies-literature
| S-EPMC5406542 | biostudies-literature
| S-EPMC5655194 | biostudies-literature
| S-EPMC4142832 | biostudies-literature
| S-EPMC3443109 | biostudies-literature