Ontology highlight
ABSTRACT:
SUBMITTER: Dwichandra Putra O
PROVIDER: S-EPMC6027452 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Dwichandra Putra Okky O Umeda Daiki D Fujita Eriko E Haraguchi Tamami T Uchida Takahiro T Yonemochi Etsuo E Uekusa Hidehiro H
Pharmaceutics 20180526 2
Benexate, a drug used clinically as a defensive type anti-ulcer agent, has poor solubility and a bitter taste. To improve its solubility, a crystal engineering approach was proposed with the formation of novel salts using an artificial sweetener as a salt co-former. This was also expected to address the bitter taste of the drug. In this work, we report on the preparation and evaluation of the physicochemical properties of the novel salts benexate saccharinate monohydrate and benexate cyclamate w ...[more]