The Roles of MDM2 and MDMX in Cancer.
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ABSTRACT:
SUBMITTER: Karni-Schmidt O
PROVIDER: S-EPMC6028239 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
The Roles of MDM2 and MDMX in Cancer.
Karni-Schmidt Orit O Lokshin Maria M Prives Carol C
Annual review of pathology 20160317
For more than 25 years, MDM2 and its homolog MDMX (also known as MDM4) have been shown to exert oncogenic activity. These two proteins are best understood as negative regulators of the p53 tumor suppressor, although they may have additional p53-independent roles. Understanding the dysregulation of MDM2 and MDMX in human cancers and how they function either together or separately in tumorigenesis may improve methods of diagnosis and for assessing prognosis. Targeting the proteins themselves, or t ...[more]
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