Ontology highlight
ABSTRACT:
SUBMITTER: Kelliher MT
PROVIDER: S-EPMC6028532 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Kelliher Michael T MT Yue Yang Y Ng Ashley A Kamiyama Daichi D Huang Bo B Verhey Kristen J KJ Wildonger Jill J
The Journal of cell biology 20180504 7
Neuronal polarity relies on the selective localization of cargo to axons or dendrites. The molecular motor kinesin-1 moves cargo into axons but is also active in dendrites. This raises the question of how kinesin-1 activity is regulated to maintain the compartment-specific localization of cargo. Our in vivo structure-function analysis of endogenous <i>Drosophila melanogaster</i> kinesin-1 reveals a novel role for autoinhibition in enabling the dendrite-specific localization of Golgi outposts. Mu ...[more]