Ontology highlight
ABSTRACT:
SUBMITTER: Lopes CAM
PROVIDER: S-EPMC6028540 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Lopes Carla A M CAM Mesquita Marta M Cunha Ana Isabel AI Cardoso Joana J Carapeta Sara S Laranjeira Cátia C Pinto António E AE Pereira-Leal José B JB Dias-Pereira António A Bettencourt-Dias Mónica M Chaves Paula P
The Journal of cell biology 20180508 7
Centrosome abnormalities are a typical hallmark of human cancers. However, the origin and dynamics of such abnormalities in human cancer are not known. In this study, we examined centrosomes in Barrett's esophagus tumorigenesis, a well-characterized multistep pathway of progression, from the premalignant condition to the metastatic disease. This human cancer model allows the study of sequential steps of progression within the same patient and has representative cell lines from all stages of dise ...[more]