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Complex ecological interactions of Staphylococcus aureus in tampons during menstruation.

ABSTRACT: Menstrual toxic shock syndrome (mTSS) is a severe disease that occurs in healthy women vaginally colonized by Staphylococcus aureus producing toxic shock toxin 1 and who use tampons. The aim of the present study was to determine the impact of the composition of vaginal microbial communities on tampon colonisation by S. aureus during menses. We analysed the microbiota in menstrual fluids extracted from tampons from 108 healthy women and 7 mTSS cases. Using culture, S. aureus was detected in menstrual fluids of 40% of healthy volunteers and 100% of mTSS patients. Between class analysis of culturomic and 16S rRNA gene metabarcoding data indicated that the composition of the tampons' microbiota differs according to the presence or absence of S. aureus and identify discriminating genera. However, the bacterial communities of tampon fluid positive for S. aureus did not cluster together. No difference in tampon microbiome richness, diversity, and ecological distance was observed between tampon vaginal fluids with or without S. aureus, and between healthy donors carrying S. aureus and mTSS patients. Our results show that the vagina is a major niche of. S. aureus in tampon users and the composition of the tampon microbiota control its virulence though more complex interactions than simple inhibition by lactic acid-producing bacterial species.

SUBMITTER: Jacquemond I

PROVIDER: S-EPMC6028614 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Complex ecological interactions of Staphylococcus aureus in tampons during menstruation.

Jacquemond Isaline I Muggeo Anaëlle A Lamblin Gery G Tristan Anne A Gillet Yves Y Bolze Pierre Adrien PA Bes Michèle M Gustave Claude Alexandre CA Rasigade Jean-Philippe JP Golfier François F Ferry Tristan T Dubost Audrey A Abrouk Danis D Barreto Samuel S Prigent-Combaret Claire C Thioulouse Jean J Lina Gérard G Muller Daniel D

Scientific reports 20180702 1

Menstrual toxic shock syndrome (mTSS) is a severe disease that occurs in healthy women vaginally colonized by Staphylococcus aureus producing toxic shock toxin 1 and who use tampons. The aim of the present study was to determine the impact of the composition of vaginal microbial communities on tampon colonisation by S. aureus during menses. We analysed the microbiota in menstrual fluids extracted from tampons from 108 healthy women and 7 mTSS cases. Using culture, S. aureus was detected in menst ...[more]

PMID: 29967393

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Complex ecological interactions of Staphylococcus aureus in tampons during menstruation.

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Complex ecological interactions of Staphylococcus aureus in tampons during menstruation.

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