Ontology highlight
ABSTRACT:
SUBMITTER: Khairnar V
PROVIDER: S-EPMC6028648 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Khairnar Vishal V Duhan Vikas V Patil Ashwini M AM Zhou Fan F Bhat Hilal H Thoens Christine C Sharma Piyush P Adomati Tom T Friendrich Sarah-Kim SK Bezgovsek Judith J Dreesen Janine D JD Wennemuth Gunther G Westendorf Astrid M AM Zelinskyy Gennadiy G Dittmer Ulf U Hardt Cornelia C Timm Jörg J Göthert Joachim R JR Lang Philipp A PA Singer Bernhard B BB Lang Karl S KS
Nature communications 20180702 1
Dysfunction of CD8<sup>+</sup> T cells can lead to the development of chronic viral infection. Identifying mechanisms responsible for such T cell dysfunction is therefore of great importance to understand how to prevent persistent viral infection. Here we show using lymphocytic choriomeningitis virus (LCMV) infection that carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is fundamental for recruiting lymphocyte-specific protein kinase (Lck) into the T cell receptor complex to f ...[more]