Ontology highlight
ABSTRACT:
SUBMITTER: Knight JM
PROVIDER: S-EPMC6028980 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Knight J Morgan JM Mandal Pijus P Morlacchi Pietro P Mak Garbo G Li Evan E Madison Matthew M Landers Cameron C Saxton Brandon B Felix Ed E Gilbert Brian B Sederstrom Joel J Varadhachary Atul A Singh Melissa M MM Chatterjee Dev D Corry David B DB McMurray John S JS
The Journal of biological chemistry 20180508 26
Asthma is a chronic inflammatory disease of the lungs and airways and one of the most burdensome of all chronic maladies. Previous studies have established that expression of experimental and human asthma requires the IL-4/IL-13/IL-4 receptor α (IL-4Rα) signaling pathway, which activates the transcription factor STAT6. However, no small molecules targeting this important pathway are currently in clinical development. To this end, using a preclinical asthma model, we sought to develop and test a ...[more]