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Transition-metal-free C-H amidation and chlorination: synthesis of N/N'-mono-substituted imidazopyridin-2-ones from N-pyridyl-N-hydroxylamine intermediates.

ABSTRACT: Non-symmetric 1,3-substituted imidazopyridin-2-ones are a common structural scaffold found among many biologically active molecules. Herein we report an efficient, mild, and transition-metal free C-H amidation strategy to access such a pyrido-fused cyclic urea framework in good yields and with a broad functional group tolerance.

SUBMITTER: Lee KN

PROVIDER: S-EPMC6029925 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Transition-metal-free C-H amidation and chlorination: synthesis of N/N'-mono-substituted imidazopyridin-2-ones from N-pyridyl-N-hydroxylamine intermediates.

Lee Katarzyna N KN Spiegowski Dominique N DN Lee Johnny W JW Lim Sanghyun S Zhao Fuhua F Ngai Ming-Yu MY

Chemical communications (Cambridge, England) 20180601 50

Non-symmetric 1,3-substituted imidazopyridin-2-ones are a common structural scaffold found among many biologically active molecules. Herein we report an efficient, mild, and transition-metal free C-H amidation strategy to access such a pyrido-fused cyclic urea framework in good yields and with a broad functional group tolerance. ...[more]

PMID: 29850673

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