Synergy of Physico-chemical and Biological Experiments for Developing a Cyclooxygenase-2 Inhibitor.
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ABSTRACT:
SUBMITTER: Singh P
PROVIDER: S-EPMC6030096 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
Synergy of Physico-chemical and Biological Experiments for Developing a Cyclooxygenase-2 Inhibitor.
Singh Palwinder P Kaur Jagroop J Kaur Harpreet H Kaur Anudeep A Bhatti Rajbir R
Scientific reports 20180703 1
The physiological consequences of COX-2 overexpression in the development of cancer, diabetes and neurodegenerative diseases have made this enzyme a promising therapeutic target. Herein, COX-2 active site was analyzed and new molecules were designed. We identified a highly potent molecule (S)-3a with IC<sub>50</sub> value and the selectivity for COX-2 0.6 nM and 1666, respectively. The MTD of (S)-3a was 2000 mg kg<sup>-1</sup> and its pharmacokinetic studies in rat showed t<sub>1/2</sub> 7.5 h. ...[more]
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