Ontology highlight
ABSTRACT:
SUBMITTER: Andrews AM
PROVIDER: S-EPMC6030175 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Andrews Alex M AM McCartney Heather J HJ Errington Tim M TM D'Andrea Alan D AD Macara Ian G IG
Nature communications 20180703 1
Interstrand DNA cross-links (ICLs) block both replication and transcription, and are commonly repaired by the Fanconi anemia (FA) pathway. However, FA-independent repair mechanisms of ICLs remain poorly understood. Here we report a previously uncharacterized protein, SAN1, as a 5' exonuclease that acts independently of the FA pathway in response to ICLs. Deletion of SAN1 in HeLa cells and mouse embryonic fibroblasts causes sensitivity to ICLs, which is prevented by re-expression of wild type but ...[more]