Ontology highlight
ABSTRACT:
SUBMITTER: Lee SJ
PROVIDER: S-EPMC6030240 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Lee Sang Jae SJ Choi Jang-Sik JS Bong Seoung Min SM Hwang Hae-Jun HJ Lee Jaesang J Song Ho-Juhn HJ Lee Jaekyoo J Kim Jung-Ho JH Koh Jong Sung JS Lee Byung Il BI
Molecules and cells 20180612 6
Spleen tyrosine kinase (SYK) is a cytosolic non-receptor protein tyrosine kinase. Because SYK mediates key receptor signaling pathways involving the B cell receptor and Fc receptors, SYK is an attractive target for autoimmune disease and cancer treatments. To date, representative oral SYK inhibitors, including fostamatinib (R406 or R788), entospletinib (GS-9973), cerdulatinib (PRT062070), and TAK-659, have been assessed in clinical trials. Here, we report the crystal structures of SYK in complex ...[more]