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Separate block-based parameter estimation method for Hammerstein systems.

ABSTRACT: Different from the output-input representation-based identification methods of two-block Hammerstein systems, this paper concerns a separate block-based parameter estimation method for each block of a two-block Hammerstein CARMA system, without combining the parameters of two parts together. The idea is to consider each block as a subsystem and to estimate the parameters of the nonlinear block and the linear block separately (interactively), by using two least-squares algorithms in one recursive step. The internal variable between the two blocks (the output of the nonlinear block, and also the input of the linear block) is replaced by different estimates: when estimating the parameters of the nonlinear part, the internal variable between the two blocks is computed by the linear function; when estimating the parameters of the linear part, the internal variable is computed by the nonlinear function. The proposed parameter estimation method possesses property of the higher computational efficiency compared with the previous over-parametrization method in which many redundant parameters need to be computed. The simulation results show the effectiveness of the proposed algorithm.

SUBMITTER: Zhang S

PROVIDER: S-EPMC6030268 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Separate block-based parameter estimation method for Hammerstein systems.

Zhang Shuo S Wang Dongqing D Liu Feng F

Royal Society open science 20180627 6

Different from the output-input representation-based identification methods of two-block Hammerstein systems, this paper concerns a separate block-based parameter estimation method for each block of a two-block Hammerstein CARMA system, without combining the parameters of two parts together. The idea is to consider each block as a subsystem and to estimate the parameters of the nonlinear block and the linear block separately (interactively), by using two least-squares algorithms in one recursive ...[more]

PMID: 30110418

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Project description:BackgroundThe importance of stochasticity in cellular processes having low number of molecules has resulted in the development of stochastic models such as chemical master equation. As in other modelling frameworks, the accompanying rate constants are important for the end-applications like analyzing system properties (e.g. robustness) or predicting the effects of genetic perturbations. Prior knowledge of kinetic constants is usually limited and the model identification routine typically includes parameter estimation from experimental data. Although the subject of parameter estimation is well-established for deterministic models, it is not yet routine for the chemical master equation. In addition, recent advances in measurement technology have made the quantification of genetic substrates possible to single molecular levels. Thus, the purpose of this work is to develop practical and effective methods for estimating kinetic model parameters in the chemical master equation and other stochastic models from single cell and cell population experimental data.ResultsThree parameter estimation methods are proposed based on the maximum likelihood and density function distance, including probability and cumulative density functions. Since stochastic models such as chemical master equations are typically solved using a Monte Carlo approach in which only a finite number of Monte Carlo realizations are computationally practical, specific considerations are given to account for the effect of finite sampling in the histogram binning of the state density functions. Applications to three practical case studies showed that while maximum likelihood method can effectively handle low replicate measurements, the density function distance methods, particularly the cumulative density function distance estimation, are more robust in estimating the parameters with consistently higher accuracy, even for systems showing multimodality.ConclusionsThe parameter estimation methodologies described in this work have provided an effective and practical approach in the estimation of kinetic parameters of stochastic systems from either sparse or dense cell population data. Nevertheless, similar to kinetic parameter estimation in other modelling frameworks, not all parameters can be estimated accurately, which is a common problem arising from the lack of complete parameter identifiability from the available data.

Dataset Information

Separate block-based parameter estimation method for Hammerstein systems.

Publications

Separate block-based parameter estimation method for Hammerstein systems.

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