Ontology highlight
ABSTRACT:
SUBMITTER: Maucuer A
PROVIDER: S-EPMC6031325 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Maucuer Alexandre A Desforges Bénédicte B Joshi Vandana V Boca Mirela M Kretov Dmitry A DA Hamon Loic L Bouhss Ahmed A Curmi Patrick A PA Pastré David D
Journal of cell science 20180611 11
Liquid-liquid phase separation enables compartmentalization of biomolecules in cells, notably RNA and associated proteins in the nucleus. Besides having critical functions in RNA processing, there is a major interest in deciphering the molecular mechanisms of compartmentalization orchestrated by RNA-binding proteins such as TDP-43 (also known as TARDBP) and FUS because of their link to neuron diseases. However, tools for probing compartmentalization in cells are lacking. Here, we developed a met ...[more]