Ontology highlight
ABSTRACT:
SUBMITTER: Saron WAA
PROVIDER: S-EPMC6031378 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Saron Wilfried A A WAA Rathore Abhay P S APS Ting Lim L Ooi Eng Eong EE Low Jenny J Abraham Soman N SN St John Ashley L AL
Science advances 20180704 7
How previous immunity influences immune memory recall and protection against related flaviviruses is largely unknown, yet encounter with multiple flaviviruses in a lifetime is increasingly likely. Using sequential challenges with dengue virus (DENV), yellow fever virus (YFV), and Japanese encephalitis virus (JEV), we induced cross-reactive cellular and humoral immunity among flaviviruses from differing serocomplexes. Antibodies against JEV enhanced DENV replication; however, JEV immunity was pro ...[more]