Ontology highlight
ABSTRACT:
SUBMITTER: Gottlieb L
PROVIDER: S-EPMC6031454 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Gottlieb Leah L Marmorstein Ronen R
Structure (London, England : 1993) 20180510 7
Co-translational N-terminal protein acetylation regulates many protein functions including degradation, folding, interprotein interactions, and targeting. Human NatA (hNatA), one of six conserved metazoan N-terminal acetyltransferases, contains Naa10 catalytic and Naa15 auxiliary subunits, and associates with the intrinsically disordered Huntingtin yeast two-hybrid protein K (HYPK). We report on the crystal structures of hNatA and hNatA/HYPK, and associated biochemical and enzymatic analyses. We ...[more]