Ontology highlight
ABSTRACT:
SUBMITTER: Mills IG
PROVIDER: S-EPMC2171420 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
Mills Ian G IG Gaughan Luke L Robson Craig C Ross Theodora T McCracken Stuart S Kelly John J Neal David E DE
The Journal of cell biology 20050701 2
Internalization of activated receptors regulates signaling, and endocytic adaptor proteins are well-characterized in clathrin-mediated uptake. One of these adaptor proteins, huntingtin interacting protein 1 (HIP1), induces cellular transformation and is overexpressed in some prostate cancers. We have discovered that HIP1 associates with the androgen receptor through a central coiled coil domain and is recruited to DNA response elements upon androgen stimulation. HIP1 is a novel androgen receptor ...[more]