Synergistic Growth Inhibitory Effects of Chrysin and Metformin Combination on Breast Cancer Cells through hTERT and Cyclin D1 Suppression
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ABSTRACT:
SUBMITTER: Rasouli S
PROVIDER: S-EPMC6031784 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Publications
Synergistic Growth Inhibitory Effects of Chrysin and Metformin Combination on Breast Cancer Cells through hTERT and Cyclin D1 Suppression
Rasouli Sara S Zarghami Nosratollah N
Asian Pacific journal of cancer prevention : APJCP 20180425 4
Objective: To explore the possibility of a novel chemopreventive strategy for improving breast cancer treatment, the anticancer effects of a combination two natural compounds, Chrysin and Metformin, against T47D breast cancer cells were investigated. Materials and Methods: After treatment of T47D cells with Metformin, Chrysin and the two drugs in combination, toxicity to cancer cells was evaluated by MTT assay. Real time PCR was then used to determine the expression levels of hTERT and cyclin D1 ...[more]
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