Dataset Information

High-frequency autonomic modulation: a new model for analysis of autonomic cardiac control.

ABSTRACT:

Background and purpose

Increase in high-frequency beat-to-beat heart rate oscillations by torsadogenic hERG blockers appears to be associated with signs of parasympathetic and sympathetic co-activation which cannot be assessed directly using classic methods of heart rate variability analysis. The present work aimed to find a translational model that would allow this particular state of the autonomic control of heart rate to be assessed.

Experimental approach

High-frequency heart rate and heart period oscillations were analysed within discrete 10 s intervals in a cohort of 200 healthy human subjects. Results were compared to data collected in non-human primates and beagle dogs during pharmacological challenges and torsadogenic hERG blockers exposure, in 127 genotyped LQT1 patients on/off β-blocker treatment and in subgroups of smoking and non-smoking subjects.

Key results

Three states of autonomic modulation, S1 (parasympathetic predominance) to S3 (reciprocal parasympathetic withdrawal/sympathetic activation), were differentiated to build a new model of heart rate variability referred to as high-frequency autonomic modulation. The S2 state corresponded to a specific state during which both parasympathetic and sympathetic systems were coexisting or co-activated. S2 oscillations were proportionally increased by torsadogenic hERG-blocking drugs, whereas smoking caused an increase in S3 oscillations.

Conclusions and implications

The combined analysis of the magnitude of high-frequency heart rate and high-frequency heart period oscillations allows a refined assessment of heart rate autonomic modulation applicable to long-term ECG recordings and offers new approaches to assessment of the risk of sudden death both in terms of underlying mechanisms and sensitivity.

SUBMITTER: Champeroux P

PROVIDER: S-EPMC6031873 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Publications

High-frequency autonomic modulation: a new model for analysis of autonomic cardiac control.

Champéroux Pascal P Fesler Pierre P Judé Sebastien S Richard Serge S Le Guennec Jean-Yves JY Thireau Jérôme J

British journal of pharmacology 20180615 15

<h4>Background and purpose</h4>Increase in high-frequency beat-to-beat heart rate oscillations by torsadogenic hERG blockers appears to be associated with signs of parasympathetic and sympathetic co-activation which cannot be assessed directly using classic methods of heart rate variability analysis. The present work aimed to find a translational model that would allow this particular state of the autonomic control of heart rate to be assessed.<h4>Experimental approach</h4>High-frequency heart r ...[more]

PMID: 29723392

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Dataset Information

High-frequency autonomic modulation: a new model for analysis of autonomic cardiac control.

Background and purpose

Experimental approach

Key results

Conclusions and implications

Publications

High-frequency autonomic modulation: a new model for analysis of autonomic cardiac control.

Similar Datasets

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