Ontology highlight
ABSTRACT:
SUBMITTER: Blum Y
PROVIDER: S-EPMC6430832 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Blum Yuna Y Meiller Clément C Quetel Lisa L Elarouci Nabila N Ayadi Mira M Tashtanbaeva Danisa D Armenoult Lucile L Montagne François F Tranchant Robin R Renier Annie A de Koning Leanne L Copin Marie-Christine MC Hofman Paul P Hofman Véronique V Porte Henri H Le Pimpec-Barthes Françoise F Zucman-Rossi Jessica J Jaurand Marie-Claude MC de Reyniès Aurélien A Jean Didier D
Nature communications 20190322 1
Malignant pleural mesothelioma (MPM) is recognized as heterogeneous based both on histology and molecular profiling. Histology addresses inter-tumor and intra-tumor heterogeneity in MPM and describes three major types: epithelioid, sarcomatoid and biphasic, a combination of the former two types. Molecular profiling studies have not addressed intra-tumor heterogeneity in MPM to date. Here, we use a deconvolution approach and show that molecular gradients shed new light on the intra-tumor heteroge ...[more]