Ontology highlight
ABSTRACT:
SUBMITTER: Melani R
PROVIDER: S-EPMC6032446 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
Melani Raffaella R Sallustio Fabio F Fardin Paolo P Vanni Cristina C Ognibene Marzia M Ottaviano Catherine C Melillo Giovanni G Varesio Luigi L Eva Alessandra A
Gene expression 20060101 3
The Dbl oncogene is a guanine nucleotide exchange factor for Rho GTPases and its activity has been linked to the regulation of gene transcription. Dbl oncogene expression in NIH3T3 cells leads to changes in morphological and proliferative properties of these cells, inducing a highly transformed phenotype. To gain insights into Dbl oncogene-induced transformation we compared gene expression profiles between Dbl oncogene-transformed and parental NIH3T3 cells by cDNA microarray. We found that Dbl o ...[more]