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Genome-wide association study of nocturnal blood pressure dipping in hypertensive patients.

ABSTRACT: BACKGROUND:Reduced nocturnal fall (non-dipping) of blood pressure (BP) is a predictor of cardiovascular target organ damage. No genome-wide association studies (GWAS) on BP dipping have been previously reported. METHODS:To study genetic variation affecting BP dipping, we conducted a GWAS in Genetics of Drug Responsiveness in Essential Hypertension (GENRES) cohort (n?=?204) using the mean night-to-day BP ratio from up to four ambulatory BP recordings conducted on placebo. Associations with P?

SUBMITTER: Rimpela JM 

PROVIDER: S-EPMC6032801 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Genome-wide association study of nocturnal blood pressure dipping in hypertensive patients.

Rimpelä Jenni M JM   Pörsti Ilkka H IH   Jula Antti A   Lehtimäki Terho T   Niiranen Teemu J TJ   Oikarinen Lasse L   Porthan Kimmo K   Tikkakoski Antti A   Virolainen Juha J   Kontula Kimmo K KK   Hiltunen Timo P TP  

BMC medical genetics 20180704 1

<h4>Background</h4>Reduced nocturnal fall (non-dipping) of blood pressure (BP) is a predictor of cardiovascular target organ damage. No genome-wide association studies (GWAS) on BP dipping have been previously reported.<h4>Methods</h4>To study genetic variation affecting BP dipping, we conducted a GWAS in Genetics of Drug Responsiveness in Essential Hypertension (GENRES) cohort (n = 204) using the mean night-to-day BP ratio from up to four ambulatory BP recordings conducted on placebo. Associati  ...[more]

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