Ontology highlight
ABSTRACT:
SUBMITTER: Gough RE
PROVIDER: S-EPMC6032930 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
FEBS letters 20180518 12
Talins are cytoplasmic adapter proteins essential for integrin-mediated cell adhesion to the extracellular matrix. Talins control the activation state of integrins, link integrins to cytoskeletal actin, recruit numerous signalling molecules that mediate integrin signalling and coordinate recruitment of microtubules to adhesion sites via interaction with KANK (kidney ankyrin repeat-containing) proteins. Vertebrates have two talin genes, TLN1 and TLN2. Although talin1 and talin2 share 76% protein ...[more]