Ontology highlight
ABSTRACT:
SUBMITTER: Bromberger T
PROVIDER: S-EPMC8417109 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Bromberger Thomas T Klapproth Sarah S Rohwedder Ina I Weber Jasmin J Pick Robert R Mittmann Laura L Min-Weißenhorn Soo Jin SJ Reichel Christoph A CA Scheiermann Christoph C Sperandio Markus M Moser Markus M
Frontiers in immunology 20210819
β2 integrins mediate key processes during leukocyte trafficking. Upon leukocyte activation, the structurally bent β2 integrins change their conformation towards an extended, intermediate and eventually high affinity conformation, which mediate slow leukocyte rolling and firm arrest, respectively. Translocation of talin1 to integrin adhesion sites by interactions with the small GTPase Rap1 and the Rap1 effector Riam precede these processes. Using Rap1 binding mutant talin1 and Riam deficient mice ...[more]