Ontology highlight
ABSTRACT:
SUBMITTER: Oseledchyk A
PROVIDER: S-EPMC6033351 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Oseledchyk Anton A Ricca Jacob M JM Gigoux Mathieu M Ko Brian B Redelman-Sidi Gil G Walther Tyler T Liu Cailian C Iyer Gopa G Merghoub Taha T Wolchok Jedd D JD Zamarin Dmitriy D
Oncotarget 20180619 47
Intratumoral therapy with oncolytic viruses is increasingly being explored as a strategy to potentiate an immune response against cancer, but it remains unknown whether such therapy should be restricted to cancers sensitive to virus-mediated lysis. Using Newcastle Disease Virus (NDV) as a model, we explore immunogenic potential of an oncolytic virus in bladder cancer, where existing immunotherapy with PD-1 and PD-L1-targeting antibodies to date has shown suboptimal response rates. Infection of h ...[more]