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Functional reorganization of the conceptual brain system after deafness in early childhood.

ABSTRACT: The neurodevelopmental consequences of deafness on the functional neuroarchitecture of the conceptual system have not been intensively investigated so far. Using functional magnetic resonance imaging (fMRI), we therefore identified brain areas involved in conceptual processing in deaf and hearing participants. Conceptual processing was probed by a pictorial animacy decision task. Furthermore, brain areas sensitive to observing verbal signs and to observing non-verbal visual hand actions were identified in deaf participants. In hearing participants, brain areas responsive to environmental sounds and the observation of visual hand actions were determined. We found a stronger recruitment of superior and middle temporal cortex in deaf compared to hearing participants during animacy decisions. This region, which forms auditory cortex in hearing people according to the sound listening task, was also activated in deaf participants, when they observed sign language, but not when they observed non-verbal hand actions. These results indicate that conceptual processing in deaf people more strongly depends on language representations compared to hearing people. Furthermore, additionally enhanced activation in visual and motor areas of deaf versus hearing participants during animacy decisions and a more frequent report of visual and motor features in the property listing task suggest that the loss of the auditory channel is partially compensated by an increased importance of visual and motor information for constituting object knowledge. Hence, our results indicate that conceptual processing in deaf compared to hearing people is more strongly based on the language system, complemented by an enhanced contribution of the visuo-motor system.

SUBMITTER: Trumpp NM

PROVIDER: S-EPMC6033386 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Functional reorganization of the conceptual brain system after deafness in early childhood.

Trumpp Natalie M NM Kiefer Markus M

PloS one 20180705 7

The neurodevelopmental consequences of deafness on the functional neuroarchitecture of the conceptual system have not been intensively investigated so far. Using functional magnetic resonance imaging (fMRI), we therefore identified brain areas involved in conceptual processing in deaf and hearing participants. Conceptual processing was probed by a pictorial animacy decision task. Furthermore, brain areas sensitive to observing verbal signs and to observing non-verbal visual hand actions were ide ...[more]

PMID: 29975699

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Project description:ObjectiveThe current study aims to investigate functional brain network representations during the early period of epileptogenesis.MethodsEighteen rats with the intrahippocampal kainate model of mesial temporal lobe epilepsy were used for this experiment. Functional magnetic resonance imaging (fMRI) measurements were made 1 week after status epilepticus, followed by 2-4-month electrophysiological and video monitoring. Animals were identified as having (1) developed epilepsy (E+, n = 9) or (2) not developed epilepsy (E-, n = 6). Nine additional animals served as controls. Graph theory analysis was performed on the fMRI data to quantify the functional brain networks in all animals prior to the development of epilepsy. Spectrum clustering with the network features was performed to estimate their predictability in epileptogenesis.ResultsOur data indicated that E+ animals showed an overall increase in functional connectivity strength compared to E- and control animals. Global network features and small-worldness of E- rats were similar to controls, whereas E+ rats demonstrated increased small-worldness, including increased reorganization degree, clustering coefficient, and global efficiency, with reduced shortest pathlength. A notable classification of the combined brain network parameters was found in E+ and E- animals. For the local network parameters, the E- rats showed increased hubs in sensorimotor cortex, and decreased hubness in hippocampus. The E+ rats showed a complete loss of hippocampal hubs, and the appearance of new hubs in the prefrontal cortex. We also observed that lesion severity was not related to epileptogenesis.SignificanceOur data provide a view of the reorganization of topographical functional brain networks in the early period of epileptogenesis and how it can significantly predict the development of epilepsy. The differences from E- animals offer a potential means for applying noninvasive neuroimaging tools for the early prediction of epilepsy.

Project description:Single-sided deafness (SSD) is an extreme case of partial hearing deprivation and results in a significant decline in higher-order hearing abilities, including sound localization and speech-in-noise recognition. Clinical studies have reported that patients with SSD recover from these higher-order hearing abilities to some extent over time. Neuroimaging studies have observed extensive brain functional plasticity in patients with SSD. However, studies investigating the role of plasticity in functional compensation, particularly those investigating the relationship between intrinsic brain activity alterations and higher-order hearing abilities, are still limited. In this study, we used resting-state functional MRI to investigate intrinsic brain activity, measured by the amplitude of low-frequency fluctuation (ALFF), in 19 patients with left SSD, 17 patients with right SSD, and 21 normal hearing controls (NHs). All patients with SSD had durations of deafness longer than 2 years. Decreased ALFF values in the bilateral precuneus (PCUN), lingual gyrus, and left middle frontal gyrus were observed in patients with SSD compared with the values of NHs. Longer durations of deafness were correlated with better hearing abilities, as well as higher ALFF values in the left inferior parietal lobule, the angular gyrus, the middle occipital gyrus, the bilateral PCUN, and the posterior cingulate gyrus. Moreover, we observed a generally consistent trend of correlation between ALFF values and higher-order hearing abilities in specific brain areas in patients with SSD. That is, better abilities were correlated with lower ALFF values in the frontal regions and higher ALFF values in the PCUN and surrounding parietal-occipital areas. Furthermore, mediation analysis revealed that the ALFF values in the PCUN were a significant mediator of the relationship between the duration of deafness and higher-order hearing abilities. Our study reveals significant plasticity of intrinsic brain activity in patients with SSD and suggests that reorganization of intrinsic brain activity may be one of the compensatory mechanisms that facilitate improvement in higher-order hearing abilities in these patients over time.

Dataset Information

Functional reorganization of the conceptual brain system after deafness in early childhood.

Publications

Functional reorganization of the conceptual brain system after deafness in early childhood.

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