Ontology highlight
ABSTRACT:
SUBMITTER: Noda M
PROVIDER: S-EPMC6033451 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Noda Masaru M Okayama Hirokazu H Kofunato Yasuhide Y Chida Shun S Saito Katsuharu K Tada Takeshi T Ashizawa Mai M Nakajima Takahiro T Aoto Keita K Kikuchi Tomohiro T Sakamoto Wataru W Endo Hisahito H Fujita Shotaro S Saito Motonobu M Momma Tomoyuki T Ohki Shinji S Kono Koji K
PloS one 20180705 7
The expression of fucosyltransferase 8, an enzyme responsible for core fucosylation encoded by FUT8, influences tumor biology and correlates with patient prognosis in several solid cancers. We hypothesized that p53 alteration modifies prognostic associations of FUT8 expression in colorectal cancer (CRC), since FUT8 has recently been identified as a direct transcriptional target of wild-type p53. Utilizing multiple datasets of microarray and RNA sequence of CRC, FUT8 mRNA was found to be highly e ...[more]