Ontology highlight
ABSTRACT:
SUBMITTER: Ichikawa S
PROVIDER: S-EPMC6033674 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20180612 28
Despite significant recent progress in copper-catalyzed enantioselective hydroamination chemistry, the synthesis of chiral N-arylamines, which are frequently found in natural products and pharmaceuticals, has not been realized. Initial experiments with N-arylhydroxylamine ester electrophiles were unsuccessful and, instead, their reduction in the presence of copper hydride (CuH) catalysts was observed. Herein, we report key modifications to our previously reported hydroamination methods that lead ...[more]