A multifunctional DNA nano-scorpion for highly efficient targeted delivery of mRNA therapeutics.

ABSTRACT: The highly efficient cancer cell targeted delivery plays an important role in precise targeted therapies. Herein, a multifunctional DNA nano-scorpion nanostructure (termed AptDzy-DNS) functioned with aptamers and DNAzyme is developed for highly efficient targeted delivery of mRNA therapeutics in gene therapy. The designed AptDzy-DNS is self-assembled with specific aptamers as "scorpion stingers" for targeting tumor cell and DNAzymes as "scorpion pincers" for targeted gene therapy by cleaving mRNA into fragments. The as-prepared AptDzy-DNS can effectively distinguish cancer cells from normal cells by specific cross-talking between aptamers on AptDzy-DNS and overexpressed cell-surface receptors. In the process of gene therapy, by reacting with Mg²⁺-dependent DNAzyme on AptDzy-DNS,

SUBMITTER: Li D 

PROVIDER: S-EPMC6033943 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature