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N-Gemini peptides: cytosolic protease resistance via N-terminal dimerization of unstructured peptides.


ABSTRACT: Herein we describe a synthetically simple strategy for increasing the lifetime of unstructured peptides in cytosolic environment via dimerization at the N-terminus to block threading into the catalytic cleft of cytosolic proteases. We establish this approach with kinase substrates, allowing for phosphorylation in cells as a demonstration of protease resistance.

SUBMITTER: Fayer EL 

PROVIDER: S-EPMC6034174 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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N-Gemini peptides: cytosolic protease resistance via N-terminal dimerization of unstructured peptides.

Fayer Effrat L EL   Gilliland William M WM   Ramsey J Michael JM   Allbritton Nancy L NL   Waters Marcey L ML  

Chemical communications (Cambridge, England) 20171201 2


Herein we describe a synthetically simple strategy for increasing the lifetime of unstructured peptides in cytosolic environment via dimerization at the N-terminus to block threading into the catalytic cleft of cytosolic proteases. We establish this approach with kinase substrates, allowing for phosphorylation in cells as a demonstration of protease resistance. ...[more]

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