Ontology highlight
ABSTRACT:
SUBMITTER: Fayer EL
PROVIDER: S-EPMC6034174 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Fayer Effrat L EL Gilliland William M WM Ramsey J Michael JM Allbritton Nancy L NL Waters Marcey L ML
Chemical communications (Cambridge, England) 20171201 2
Herein we describe a synthetically simple strategy for increasing the lifetime of unstructured peptides in cytosolic environment via dimerization at the N-terminus to block threading into the catalytic cleft of cytosolic proteases. We establish this approach with kinase substrates, allowing for phosphorylation in cells as a demonstration of protease resistance. ...[more]