Ontology highlight
ABSTRACT:
SUBMITTER: Liu YJ
PROVIDER: S-EPMC7725477 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Liu Yi-Jun YJ Zhang Ting T Cheng Daxiao D Yang Junhua J Chen Sicong S Wang Xingyue X Li Xia X Duan Duo D Lou Huifang H Zhu Liya L Luo Jianhong J Ho Margaret S MS Wang Xiao-Dong XD Duan Shumin S
Science advances 20201209 50
Organelle transport requires dynamic cytoskeleton remodeling, but whether cytoskeletal dynamics are, in turn, regulated by organelles remains elusive. Here, we demonstrate that late endosomes, a type of prelysosomal organelles, facilitate actin-cytoskeleton remodeling via cytosolic translocation of immature protease cathepsin D (cathD) during microglia migration. After cytosolic translocation, late endosome-derived cathD juxtaposes actin filaments at the leading edge of lamellipodia. Suppressing ...[more]