Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane.
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ABSTRACT:
SUBMITTER: Clulow JA
PROVIDER: S-EPMC6034444 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane.
Clulow James A JA Storck Elisabeth M EM Lanyon-Hogg Thomas T Kalesh Karunakaran A KA Jones Lyn H LH Tate Edward W EW
Chemical communications (Cambridge, England) 20170501 37
Sulforaphane is a small molecule isothiocyanate which exhibits anticancer potential, yet its biological targets remain poorly understood. Here we employ a competition-based chemical proteomics strategy to profile sulforaphane's targets and identify over 500 targets along with their relative affinities. These targets provide a new set of mediators for sulforaphane's bioactivity, and aid understanding of its complex mode of action. ...[more]
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